5-Hydroxymethylcytosine Is Correlated with TET2 or IDH1/2 Mutations However, May Not be a Prognostic Value to Predict the Survivals in Normal Karyotype AML
نویسندگان
چکیده
منابع مشابه
5-Hydroxymethylcytosine correlates with epigenetic regulatory mutations, but may not have prognostic value in predicting survival in normal karyotype acute myeloid leukemia
Stem cells display remarkably high levels of 5-hydroxymethylcytosine (5hmC). Both TET2 and IDH1/2 mutations can impair the production of 5hmC, thus decreasing 5hmC levels. TET2 or IDH1/2 mutations are commonly observed in acute myeloid leukemia (AML). However, the implications of 5hmC on survival in normal karyotype AML patients have not been fully evaluated. The 5hmC levels were analyzed in 37...
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1Munich Leukemia Laboratory GmbH, Munich, Germany; 2Institute of Hematology, University of Perugia, Perugia, Italy; 3Department of Cellular Biotechnologies and Hematology, “La Sapienza” University, Rome, Italy; 4Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy; 5Institute of Hematology “Ludovico & Ariosto Seragnoli,” University of Bologna, Bologna,...
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ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v126.23.3832.3832